Ciyuan®- Your Trusted Supplier of Marigold Extract Supplement

Marigold extract supplements have been known to have many different health benefits since they are produced out of the bright flowers of Tagetes erecta or Calendula officinalis. Their mechanism in promoting ocular health and and minimizing inflammation has been well established, but of more recent interest is their possible effectiveness in enhancing immune system activity. This paper will discuss the science behind this assertion, the main compounds of the marigold extract that act to interfere with the workings of the immune system and their roles towards the general immune resilience.
Apart of the Immune System: An Overview Summary
The immune system is a complete system of cells, tissue, and organs that seem to be fighting to strengthen the human body against unwanted creatures like bacteria, viruses, and fungus. It works in two main systems of defense: innate (the first system response to attack) and adaptive (developing specific response against definite pathogen).

The effective functionality of the immune system depends on the proper cell dynamics, proper cell communication within the immune system, and the protection of the immune system against oxidative stress all of which can be regulated by food and supplementation. Highly bioactive extracts of marigold have become a possible ally in the promotion of these immune responses.

COA

Composition:

Key Compounds in Marigold Extract and Their Immune-Boosting Potential

1. Carotenoids: Antioxidant Champions
One of the chemical compounds that are found abundantly in marigold is carotenoids such as lutein, zeaxanthin, and beta-carotene. The fat-soluble pigments are strong antioxidants; thus, they neutralise free radicals, which may destroy the immune cells and affect their performance.

Beta-carotene: The body uses beta-carotene to create vitamin A, which is essential to the integrity of mucosal barriers (e.g., in the respiratory and the digestive tract) acting as the first line of defense against pathogens. There is a heavy mucosal defence that keeps invaders off the bloodstream.
Lutein and zeaxanthin: Lutein and zeaxanthin have demonstrated the greatest ability to protect the immune system against oxidative stress and vary due to the fact that they are well known as eye health supporting carotenoids.
2. Flavonoids: Regulators of Immunity
Marigold extract also is rich in flavonoids that include quercetin and kaempferol. They are anti-inflammatory and immunomodulatory, i.e. they help control the immune system to avoid both its excessive activity (causing chronic inflammation) and its insufficiency (weakening defense capacity).

Quercetin: Blocks the release of pro-inflammatory substances, brings the immune system to a balance, in case of an infection. It also promotes cytokine formation, or signalling proteins which co-ordinate of action of immune cells.
Kaempferol: Strengthens the effects of the natural killer (NK) cells, which are a form of innate immune that attacks virus infected cells and defective/abnormal cells.
3. Triterpenoids: Promoting the activity of Immune cells
Other categories of compounds found in marigold extract are triterpenoids which were investigated to stimulate the proliferation and activity of immune cells. These compounds:

Activate the formation of white blood cells (leukocytes) among which are neutrophils and macrophages that attack and kill agents of infection.
Promote phagocytosis- the activity of immune cells with which foreign bodies are ingested and destroyed.

How Marigold Extract Supplement Enhances Immune Function

1. Innate Immunity fortification
The innate immune system offers short-term and non-specific defense to the pathogens. Marigold extract has the following ways of supporting this system:

Stimulating NK cells: NK cells play an important role in initial virus and bacterial defense. Research indicates that the flavonoids and triterpenoids in marigold stimulate NK cell cytotoxicity and give it the capacity to kill infected cells faster.
Improving the performance of macrophages: Macrophages are scavengers and eliminate the debris and pathogens. The compounds of marigold extract activate macrophages enabling them to respond to the presence of invaders better.
Mucosal protection: Mucosal barriers have a protective effect depending on the carotenoids carried in the marigold extract to support mucosal linings in the gut, lungs, and upper airways. The robust barrier minimizes the entry of pathogens, which decreases the risk of infections.
2. Regulating the Adaptive Immunity
The adaptive immune system generates long term immunity with the help of specialized cells (T cells and B cells), which remember the pathogen. Marigold extract can be helpful in this system, by:

Synthesis of T cell proliferation: T cells regulate immune responses, and cause direct cell death of infected cells. The triterpenoids found in Marigold have also been found to stimulate the growth of T cells which increases the capacity of the body to generate focused defenses.
Assisting in production of antibodies: The production of the antibodies is assisted by the B cells which neutralize the pathogens. Marigold extract contains flavonoids that can stimulate B cells, which speed up the production of antibodies when illnesses strike.
3. Lowering Oxidative Stress, Inflammation.
The immune response may also be compromised due to chronic oxidative stress and inflammation by altering immune signaling and by killing cells. Marigold extract helps with this by:

Antioxidant activity: Antioxidant activity: Carotenoids and flavonoid help neutralize the free radicals, helping to spare the immune cells and maintaining their functional capability.
Anti-inflammatory: Components such as triterpenoids also block against pro-inflammatory enzymes (e.g. cyclooxygenase), limiting too much inflammation, which may hinder immune system responses. This is vital because acute inflammation is required during combating infections, whereas chronic inflammation undermines the capabilities.

Supporting Evidence: Research and Traditional Use

Traditional Applications
Marigold has found use over a long period of time as a herbal remedy in the treatment of infectious diseases and in the process of wound healing, which depends on a healthy immune system. Marigold extracts were used topically in ancient civilizations to treat and prevent infection to cuts and burns however, oral preparations were used to treat irritation in the digestive tract indirectly treating gut-associated immunity.

Contemporary Science in the Field
In a 2018 study in the Phytomedicine journal, marigold extract was shown to boost the activity of NK cells and macrophages in lab models, indicating a boost in innate immune potential.
A study conducted by Journal of Ethnopharmacology (2020) has revealed that marigold flavonoid stimulated the proliferation of T cells and B cells that aids adaptive immunity.
A 2021 clinical trial found that over 12 weeks, taking an extract of marigold daily in healthy adults resulted in increased levels of antioxidants in the blood, decreased levels of measures of inflammation in the blood, and a decrease in the number of colds reported.

​​​​​​​​​​​​​​

Certificates

​​​​​​​

Exhibition

About US

Manufacture

FAQ

Q1:What about your standard delivery time?

A: For sample orders less than 25kgs, the delivery is within 3 days. For bulk order normally the delivery time is 7-10 days. For urgent order pls kindly double check with our sales before orders confirmed.

Q2:Is there any discount?

A:Sure, Prices are closely related to the quantity. The more, the cheaper.

Q3:Can you provide samples?

A:Yes, normally we can provide FREE samples 5-20 g based on shipping cost at customer’s account.

Q4:Do you have guarantee on your products?

A:The product are 100% pure natural with high quality. We are sure that every batch comes with the unique COA. All extracts are tested in-house; random extracts are tested by authoritative analytical labs.

Q5: What is your MOQ?

A: For most of the products the MOQ is 1kg. But for some of the products we can accept less quantity such as 100g.

Q6: What’s your payment terms?

A: Payment terms such as T/T, Visa Card, Master Card, e-Checking, Paypal, Western Union and Alibaba Trade Assurance are all workable. 2023 New batch Maca Root Extract Powder Nutritious Top grade Maca Extract Powder

Q7:How to ship and delivery?

A: For sample order we always ship via express such as DHL,UPS,TNT, FEDEX, EMS. For bulk orders, air or sea shipment is common.

Q8:Can you supply OEM or ODM service?

A: For sure as is known Ciyuan Biotechnology is specially on producing herb extract; OEM tables, capsules and small packing. For Sure we are the best partner of OEM&ODM supplier.